Magnetism in heavy-fermion U(Pt,Pd)3 studied by mSR

We report mSR experiments carried out on a series of heavy-electron pseudobinary compounds U(Pt1-xPdx)3 (x<=0.05). For x<=0.005 the zero-field muon depolarisation is described by the Kubo-Toyabe function. However the temperature variation of the Kubo-Toyabe relaxation rate does not show any sign of the small-moment antiferromagnetic phase with TN~6 K (signalled by neutron diffraction), in contrast to previous reports. The failure to detect the small ordered moment suggests it has a fluctuating (> 10 MHz) nature, which is consistent with the interpretation of NMR data. For 0.01<=x<=0.05 the muon depolarisation in the ordered state is described by two terms of equal amplitude: an exponentially damped spontaneous oscillation and a Lorentzian Kubo-Toyabe function. These terms are associated with antiferromagnetic order with substantial moments. The Knight-shift measured in a magnetic field of 0.6 T on single-crystalline U(Pt0.95Pd0.05)3 in the paramagnetic state shows two signals for B perpendicular to c, while only one signal is observed for B||c. The observation of two signals for B perpendicular to c, while there is only one muon localisation site (0,0,0), points to the presence of two spatially distinct regions of different magnetic response.Comment: 25 pages including 12 figures (PS), J. Phys.: Condens. Matter, in prin

The tumour microenvironment links complement system dysregulation and hypoxic signalling.

The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated processes such as increased proliferation, angiogenesis and migration. Several cellular members of the tumour microenvironment express and/or produce complement proteins locally, including tumour cells. Dysregulation of the complement system has been reported in numerous tumours and increased expression of complement activation fragments in cancer patient specimens correlates with poor patient prognosis. Importantly, genetic or pharmacological targeting of complement has been shown to reduce tumour growth in several cancer preclinical models, suggesting that complement could be an attractive therapeutic target. Hypoxia (low oxygen) is frequently found in solid tumours and has a profound biological impact on cellular and non-cellular components of the tumour microenvironment. In this review, we focus on hypoxia since this is a prevailing feature of the tumour microenvironment that, like increased complement, is typically associated with poor prognosis. Furthermore, interesting links between hypoxia and complement have been recently proposed but never collectively reviewed. Here, we explore how hypoxia alters regulation of complement proteins in different cellular components of the tumour microenvironment, as well as the downstream biological consequences of this regulation

Weak magnetism phenomena in heavy-fermion superconductors: selected μ\muSR studies

The behavior of the so-called weak moment antiferromagnetic states, observed in the heavy-fermion superconductors UPt$_3$ and URu$_2$Si$_2$, is discussed in view of recent $\mu$SR results obtained as function of control parameters like chemical substitution and external pressure. In UPt$_3$, the Pd substitution for Pt reveals the dynamical character of the weak moment order. On the other hand, $\mu$SR measurements performed on samples in which Th substitutes U suggest that crystallographic disorder on the magnetic sites deeply affects the fluctuation timescale. In URu$_2$Si$_2$, a phase separation between the so-called hidden order state, present at ambient pressure, and an antiferromagnetic state, occurring under pressure, is observed. In view of the pressure-temperature phase diagram obtained by $\mu$SR, it is deduced that the respective order parameters have different symmetries.Comment: To appear in: J. Phys.: Cond. Matte

Mean-field methods in evolutionary duplication-innovation-loss models for the genome-level repertoire of protein domains

We present a combined mean-field and simulation approach to different models describing the dynamics of classes formed by elements that can appear, disappear or copy themselves. These models, related to a paradigm duplication-innovation model known as Chinese Restaurant Process, are devised to reproduce the scaling behavior observed in the genome-wide repertoire of protein domains of all known species. In view of these data, we discuss the qualitative and quantitative differences of the alternative model formulations, focusing in particular on the roles of element loss and of the specificity of empirical domain classes.Comment: 10 Figures, 2 Table

Low-speed impact craters in loose granular media

We report on craters formed by balls dropped into dry, non-cohesive, granular media. By explicit variation of ball density $\rho_{b}$, diameter $D_{b}$, and drop height $H$, the crater diameter is confirmed to scale as the 1/4 power of the energy of the ball at impact: $D_{c}\sim(\rho_{b}{D_{b}}^{3}H)^{1/4}$. Against expectation, a different scaling law is discovered for the crater depth: $d\sim({\rho_{b}}^{3/2}{D_{b}}^{2}H)^{1/3}$. The scaling with properties of the medium is also established. The crater depth has significance for granular mechanics in that it relates to the stopping force on the ball.Comment: experiment; 4 pages, 3 figure

Evidence for spin liquid ground state in SrDy2_2O4_4 frustrated magnet probed by muSR

Muon spin relaxation ($\mu$SR) measurements were carried out on SrDy$_2$O$_4$, a frustrated magnet featuring short range magnetic correlations at low temperatures. Zero-field muon spin depolarization measurements demonstrate that fast magnetic fluctuations are present from $T=300$ K down to 20 mK. The coexistence of short range magnetic correlations and fluctuations at $T=20$ mK indicates that SrDy$_2$O$_4$ features a spin liquid ground state. Large longitudinal fields affect weakly the muon spin depolarization, also suggesting the presence of fast fluctuations. For a longitudinal field of $\mu_0H=2$ T, a non-relaxing asymmetry contribution appears below $T=6$ K, indicating considerable slowing down of the magnetic fluctuations as field-induced magnetically-ordered phases are approached.Comment: 6 pages, 4 figures, to be published as a proceeding of HFM2016 in Journal of Physics: Conference Series (JPCS

The Anti-Coincidence Detector for the GLAST Large Area Telescope

This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT). The ACD is LAT first-level defense against the charged cosmic ray background that outnumbers the gamma rays by 3-5 orders of magnitude. The ACD covers the top and 4 sides of the LAT tracking detector, requiring a total active area of ~8.3 square meters. The ACD detector utilizes plastic scintillator tiles with wave-length shifting fiber readout. In order to suppress self-veto by shower particles at high gamma-ray energies, the ACD is segmented into 89 tiles of different sizes. The overall ACD efficiency for detection of singly charged relativistic particles entering the tracking detector from the top or sides of the LAT exceeds the required 0.9997.Comment: 33 pages, 19 figure